Irena Dubrovna, a beautiful and mysterious Serbian-born fashion artist living in New York City, falls in love with and marries average-Joe American Oliver Reed. Their marriage suffers though, as Irena believes that she suffers from an ancient curse- whenever emotionally aroused, she will turn into a panther and kill. Oliver thinks that is absurd and childish, so he sends her to psychiatrist Dr. Judd to cure her. Easier said than done...

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